LEKTI

SPINK5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H0Z, 1HDL, 1UUC, 1UVF, 1UVG
Identifiers
Aliases	SPINK5, LEKTI, LETKI, NETS, NS, VAKTI, serine peptidase inhibitor, Kazal type 5, serine peptidase inhibitor Kazal type 5
External IDs	OMIM: 605010; MGI: 1919682; HomoloGene: 4987; GeneCards: SPINK5; OMA:SPINK5 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	148,137,382 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	44,155,568 bp
RNA expression pattern
	Top expressed in
	vulva; ; gums; ; skin of thigh; ; gingival epithelium; ; oral cavity; ; mucosa of pharynx; ; human penis; ; skin of hip; ; skin of arm; ; body of tongue;
	Top expressed in
	skin of abdomen; ; esophagus; ; skin of external ear; ; lip; ; skin of back; ; prostate; ; lobe of prostate; ; umbilical cord; ; left lung lobe; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum membrane; cell cortex; endoplasmic reticulum; perinuclear region of cytoplasm; epidermal lamellar body; extracellular region; intracellular membrane-bounded organelle;
Biological process	epidermal cell differentiation; negative regulation of proteolysis; negative regulation of serine-type peptidase activity; negative regulation of peptidase activity; epithelial cell differentiation; hair cell differentiation; extracellular matrix organization; negative regulation of antibacterial peptide production; negative regulation of immune response; regulation of cell adhesion; negative regulation of angiogenesis; negative regulation of serine-type endopeptidase activity; regulation of T cell differentiation; cornification; regulation of timing of anagen;
	Sources:Amigo / QuickGO
Orthologs
	11005
	72432
	ENSG00000133710
	ENSMUSG00000055561
	Q9NQ38
	Q148R4
	NM_001127698; NM_001127699; NM_006846
	NM_001081180
	NP_001121170; NP_001121171; NP_006837
	NP_001074649
	Wikidata
View/Edit Human	View/Edit Mouse

Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133710 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055561 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Magert HJ, Standker L, Kreutzmann P, Zucht HD, Reinecke M, Sommerhoff CP, Fritz H, Forssmann WG (Aug 1999). "LEKTI, a novel 15-domain type of human serine proteinase inhibitor". J Biol Chem. 274 (31): 21499–502. doi:10.1074/jbc.274.31.21499. PMID 10419450.
^ "Entrez Gene: SPINK5 serine peptidase inhibitor, Kazal type 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133710 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055561 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10419450-5] Magert HJ, Standker L, Kreutzmann P, Zucht HD, Reinecke M, Sommerhoff CP, Fritz H, Forssmann WG (Aug 1999). "LEKTI, a novel 15-domain type of human serine proteinase inhibitor". J Biol Chem. 274 (31): 21499–502. doi:10.1074/jbc.274.31.21499. PMID 10419450.

[entrez-6] "Entrez Gene: SPINK5 serine peptidase inhibitor, Kazal type 5".

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