LHX1

LHX1
Identifiers
Aliases	LHX1, LIM-1, LIM1, LIM homeobox 1
External IDs	OMIM: 601999; MGI: 99783; HomoloGene: 4068; GeneCards: LHX1; OMA:LHX1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	36,944,612 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	84,416,361 bp
RNA expression pattern
	Top expressed in
	cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; human kidney; ; gonad; ; hypothalamus; ; right uterine tube; ; substantia nigra; ; ventricular zone;
	Top expressed in
	hypoblast; ; suprachiasmatic nucleus; ; connecting tubule; ; mesoderm; ; mesorchium; ; intermediate mesoderm; ; paramesonephric duct; ; lobe of cerebellum; ; glomerulus; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; metal ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; cis-regulatory region sequence-specific DNA binding;
Cellular component	intracellular anatomical structure; nucleus; protein-containing complex; transcription regulator complex;
Biological process	pattern specification process; pronephros development; oviduct epithelium development; cell differentiation; renal system development; ureteric bud development; positive regulation of branching involved in ureteric bud morphogenesis; mesonephric tubule development; regulation of transcription, DNA-templated; retina layer formation; comma-shaped body morphogenesis; spinal cord association neuron differentiation; embryonic pattern specification; mesonephric duct development; uterine epithelium development; kidney development; positive regulation of gastrulation; vagina development; metanephric glomerulus development; cell-cell signaling; somite rostral/caudal axis specification; anatomical structure morphogenesis; gastrulation with mouth forming second; cerebellar Purkinje cell differentiation; cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; anatomical structure formation involved in morphogenesis; head development; metanephric renal vesicle morphogenesis; transcription by RNA polymerase II; post-embryonic development; cellular response to fibroblast growth factor stimulus; renal vesicle morphogenesis; lateral motor column neuron migration; cerebellum development; nervous system development; transcription, DNA-templated; nephric duct elongation; ventral spinal cord development; cervix development; uterus development; positive regulation of transcription, DNA-templated; epithelium development; mesonephros development; multicellular organism development; metanephric comma-shaped body morphogenesis; telencephalon development; branching involved in ureteric bud morphogenesis; forebrain regionalization; positive regulation of anterior head development; metanephric part of ureteric bud development; S-shaped body morphogenesis; retina development in camera-type eye; nephric duct morphogenesis; oviduct development; spinal cord development; embryonic retina morphogenesis in camera-type eye; animal organ morphogenesis; regulation of gene expression; paramesonephric duct development; urogenital system development; embryonic viscerocranium morphogenesis; metanephric S-shaped body morphogenesis; endoderm formation; anterior/posterior axis specification; horizontal cell localization; positive regulation of embryonic development; motor neuron axon guidance; dorsal/ventral pattern formation; negative regulation of transcription, DNA-templated; metanephros development; primitive streak formation; ectoderm formation; anterior/posterior pattern specification; positive regulation of nephron tubule epithelial cell differentiation; dorsal spinal cord interneuron posterior axon guidance; regulation of transcription by RNA polymerase II; neuron differentiation; positive regulation of transcription by RNA polymerase II; ureter morphogenesis; endoderm development; mesendoderm development;
	Sources:Amigo / QuickGO
Orthologs
	3975
	16869
	ENSG00000273706; ENSG00000274577
	ENSMUSG00000018698
	P48742; Q58F18
	P63006
	NM_005568
	NM_008498
	NP_005559; NP_005559.2
	NP_032524
	Wikidata
View/Edit Human	View/Edit Mouse

LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene.^[5] This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for control of differentiation and development of neural and lymphoid cells. It is also key in development of renal and urogenital systems and is required for normal organogenesis.^[6] A similar protein in mice is an essential regulator of the vertebrate head organizer.^[5]

^ ^a ^b ^c ENSG00000274577 GRCh38: Ensembl release 89: ENSG00000273706, ENSG00000274577 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018698 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: LHX1 LIM homeobox 1".
^ Dormoy V, et al. (2011). "LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma". Oncogene. 30 (15): 1753–1763. doi:10.1038/onc.2010.557. PMID 21132009.

[refGRCh38Ensembl-1] ENSG00000274577 GRCh38: Ensembl release 89: ENSG00000273706, ENSG00000274577 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018698 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LHX1 LIM homeobox 1".

[Dormoy-6] Dormoy V, et al. (2011). "LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma". Oncogene. 30 (15): 1753–1763. doi:10.1038/onc.2010.557. PMID 21132009.

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