LILRA4

LILRA4
Identifiers
Aliases	LILRA4, CD85g, ILT7, leukocyte immunoglobulin like receptor A4
External IDs	OMIM: 607517; HomoloGene: 69118; GeneCards: LILRA4; OMA:LILRA4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,339,162 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; testicle; ; lymph node; ; monocyte; ; blood; ; appendix; ; C1 segment; ; gonad; ; substantia nigra;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signaling receptor binding; coreceptor activity;
Cellular component	membrane; integral component of membrane; integral component of plasma membrane; Fc-epsilon receptor I complex; plasma membrane;
Biological process	immune system process; negative regulation of interferon-alpha production; negative regulation of tumor necrosis factor production; negative regulation of toll-like receptor 7 signaling pathway; negative regulation of toll-like receptor 9 signaling pathway; Fc-epsilon receptor signaling pathway; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	23547
	n/a
	ENSG00000277092; ENSG00000276798; ENSG00000274185; ENSG00000239961
	n/a
	P59901
	n/a
	NM_012276
	n/a
	NP_036408
	n/a
	Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILR-A5) also known as CD85 antigen-like family member G (CD85g), and immunoglobulin-like transcript 7 (ILT-7) is a protein that in humans is encoded by the LILRA4 gene.^[3]^[4]

This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.^[4]

^ ^a ^b ^c ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
^ ^a ^b "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".

[refGRCh38Ensembl-1] ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10941842-3] Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.

[entrez-4] "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".

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