LILRB3

LILRB3
Identifiers
Aliases	LILRB3, CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIRB, PIR-B, leukocyte immunoglobulin like receptor B3
External IDs	OMIM: 604820; MGI: 1195974; HomoloGene: 134028; GeneCards: LILRB3; OMA:LILRB3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,223,506 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; monocyte; ; spleen; ; upper lobe of left lung; ; appendix; ; right lung; ; bone marrow; ; bone marrow cells; ; right coronary artery;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; amyloid-beta binding; signaling receptor activity;
Cellular component	membrane; integral component of membrane; integral component of plasma membrane; plasma membrane; secretory granule membrane;
Biological process	immune system process; adaptive immune response; defense response; cell surface receptor signaling pathway; negative regulation of osteoclast differentiation; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	11025
	18729
	ENSG00000275019; ENSG00000274587; ENSG00000277816; ENSG00000204577
	n/a
	Q6PI73; O75022
	n/a
	NM_001081450; NM_006864; NM_001320960
	NM_001289428; NM_008848; NM_011093
	XP_006726238.1; XP_006726376; XP_006726377; XP_011546876; XP_011546877
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.^[4]^[5]^[6]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells and is believed to be a myeloid checkpoint. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]

^ ^a ^b ^c ENSG00000274587, ENSG00000277816, ENSG00000204577 GRCh38: Ensembl release 89: ENSG00000275019, ENSG00000274587, ENSG00000277816, ENSG00000204577 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arm JP, Nwankwo C, Austen KF (Sep 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". J Immunol. 159 (5): 2342–9. doi:10.4049/jimmunol.159.5.2342. PMID 9278324.
^ Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". J Exp Med. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.
^ ^a ^b "Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3".

[refGRCh38Ensembl-1] ENSG00000274587, ENSG00000277816, ENSG00000204577 GRCh38: Ensembl release 89: ENSG00000275019, ENSG00000274587, ENSG00000277816, ENSG00000204577 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9278324-4] Arm JP, Nwankwo C, Austen KF (Sep 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". J Immunol. 159 (5): 2342–9. doi:10.4049/jimmunol.159.5.2342. PMID 9278324.

[pmid9382880-5] Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". J Exp Med. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.

[entrez-6] "Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3".

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