LIN7A

LIN7A
Identifiers
Aliases	LIN7A, LIN-7A, LIN7, MALS-1, TIP-33, VELI1, lin-7 homolog A, crumbs cell polarity complex component, MALS1
External IDs	OMIM: 603380; MGI: 2135609; HomoloGene: 20976; GeneCards: LIN7A; OMA:LIN7A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	80,937,934 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	107,257,335 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; retinal pigment epithelium; ; primary visual cortex; ; trabecular bone; ; blood; ; cerebellar cortex; ; cerebellar hemisphere; ; entorhinal cortex;
	Top expressed in
	lobe of cerebellum; ; seminiferous tubule; ; cerebellar vermis; ; lateral septal nucleus; ; lumbar spinal ganglion; ; nucleus accumbens; ; neural layer of retina; ; primary motor cortex; ; inferior colliculi; ; superior cervical ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; L27 domain binding;
Cellular component	postsynaptic membrane; membrane; postsynaptic density; cell-cell junction; bicellular tight junction; plasma membrane; cell junction; basolateral plasma membrane; neuron projection; extracellular exosome; presynapse; synapse; MPP7-DLG1-LIN7 complex; intracellular anatomical structure;
Biological process	protein localization to basolateral plasma membrane; maintenance of epithelial cell apical/basal polarity; protein transport; synaptic vesicle transport; inner ear development; neurotransmitter secretion; exocytosis; transport; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	8825
	108030
	ENSG00000111052
	ENSMUSG00000019906
	O14910
	Q8JZS0
	NM_004664; NM_001324423
	NM_001033223; NM_001039354; NM_001284329
	NP_001311352; NP_004655
	NP_001028395; NP_001034443; NP_001271258
	Wikidata
View/Edit Human	View/Edit Mouse

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111052 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019906 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.
^ Bohl J, Brimer N, Lyons C, Vande Pol SB (Mar 2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J Biol Chem. 282 (13): 9392–400. doi:10.1074/jbc.M610002200. PMID 17237226.
^ "Entrez Gene: LIN7A lin-7 homolog A (C. elegans)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111052 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019906 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10341223-5] Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.

[pmid17237226-6] Bohl J, Brimer N, Lyons C, Vande Pol SB (Mar 2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J Biol Chem. 282 (13): 9392–400. doi:10.1074/jbc.M610002200. PMID 17237226.

[entrez-7] "Entrez Gene: LIN7A lin-7 homolog A (C. elegans)".

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