LIN7B

LIN7B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DKR
Identifiers
Aliases	LIN7B, LIN-7B, MALS-2, MALS2, VELI2, lin-7 homolog B, crumbs cell polarity complex component
External IDs	OMIM: 612331; MGI: 1330858; HomoloGene: 22648; GeneCards: LIN7B; OMA:LIN7B - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,118,460 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,020,007 bp
RNA expression pattern
	Top expressed in
	anterior cingulate cortex; ; endothelial cell; ; right frontal lobe; ; nucleus accumbens; ; Brodmann area 9; ; anterior pituitary; ; prefrontal cortex; ; amygdala; ; caudate nucleus; ; putamen;
	Top expressed in
	facial motor nucleus; ; motor neuron; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; substantia nigra; ; barrel cortex; ; primary motor cortex; ; anterior amygdaloid area; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; protein domain specific binding; L27 domain binding; protein binding;
Cellular component	postsynaptic membrane; postsynaptic density; membrane; cell-cell junction; bicellular tight junction; plasma membrane; cell junction; basolateral plasma membrane; neuron projection; presynapse; synapse; MPP7-DLG1-LIN7 complex;
Biological process	protein localization to basolateral plasma membrane; maintenance of epithelial cell apical/basal polarity; protein transport; neurotransmitter secretion; exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	64130
	22342
	ENSG00000104863
	ENSMUSG00000003872
	Q9HAP6
	O88951
	NM_001308419; NM_022165
	NM_011698
	NP_001295348; NP_071448
	NP_035828
	Wikidata
View/Edit Human	View/Edit Mouse

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104863 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003872 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.
^ "Entrez Gene: LIN7B lin-7 homolog B (C. elegans)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104863 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003872 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10341223-5] Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.

[entrez-6] "Entrez Gene: LIN7B lin-7 homolog B (C. elegans)".

[1]

[2]

[3]

[4]

[5]

[6]