LIN7C

LIN7C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LRA
Identifiers
Aliases	LIN7C, LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3, lin-7 homolog C, crumbs cell polarity complex component
External IDs	OMIM: 612332; MGI: 1330839; HomoloGene: 22649; GeneCards: LIN7C; OMA:LIN7C - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	27,506,769 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	109,731,348 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; germinal epithelium; ; epithelium of nasopharynx; ; retinal pigment epithelium; ; tibia; ; oral cavity; ; Brodmann area 23; ; visceral pleura; ; parietal pleura; ; kidney tubule;
	Top expressed in
	olfactory epithelium; ; lobe of cerebellum; ; medial ganglionic eminence; ; median eminence; ; pineal gland; ; cerebellar vermis; ; zygote; ; tail of embryo; ; dentate gyrus; ; superior cervical ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; cytoskeletal protein binding; L27 domain binding; PDZ domain binding;
Cellular component	cytoplasm; postsynaptic membrane; postsynaptic density; membrane; cell-cell junction; bicellular tight junction; plasma membrane; MPP7-DLG1-LIN7 complex; cell junction; basolateral plasma membrane; neuron projection; presynapse; synapse; glutamatergic synapse;
Biological process	protein localization to basolateral plasma membrane; maintenance of epithelial cell apical/basal polarity; protein transport; morphogenesis of an epithelial sheet; neurotransmitter secretion; exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	55327
	22343
	ENSG00000148943
	ENSMUSG00000027162
	Q9NUP9
	O88952
	NM_018362
	NM_011699
	NP_060832
	NP_035829
	Wikidata
View/Edit Human	View/Edit Mouse

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148943 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027162 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.
^ "Entrez Gene: LIN7C lin-7 homolog C (C. elegans)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148943 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027162 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10341223-5] Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.

[entrez-6] "Entrez Gene: LIN7C lin-7 homolog C (C. elegans)".

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