LMTK2

LMTK2
Identifiers
Aliases	LMTK2, AATYK2, BREK, KPI-2, KPI2, LMR2, PPP1R100, cprk, hBREK, lemur tyrosine kinase 2
External IDs	OMIM: 610989; MGI: 3036247; HomoloGene: 8948; GeneCards: LMTK2; OMA:LMTK2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	98,209,638 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	144,125,022 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus; ; primary visual cortex; ; lateral nuclear group of thalamus; ; pons; ; parotid gland; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	Paneth cell; ; primary motor cortex; ; cingulate gyrus; ; prefrontal cortex; ; olfactory tubercle; ; piriform cortex; ; superior colliculus; ; retinal pigment epithelium; ; subiculum; ; inferior colliculi;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; myosin VI binding; protein serine/threonine kinase activity; protein binding; protein phosphatase inhibitor activity; ATP binding; receptor tyrosine kinase; transmembrane signaling receptor activity; transmembrane receptor protein tyrosine kinase activity;
Cellular component	integral component of membrane; recycling endosome; Golgi apparatus; membrane; early endosome; perinuclear region of cytoplasm; cytosol; growth cone; neuronal cell body; cytoplasm; integral component of plasma membrane; receptor complex;
Biological process	transferrin transport; phosphorylation; protein phosphorylation; early endosome to late endosome transport; receptor recycling; peptidyl-serine phosphorylation; endocytic recycling; protein autophosphorylation; peptidyl-threonine phosphorylation; negative regulation of phosphoprotein phosphatase activity; negative regulation of signal transduction; peptidyl-tyrosine phosphorylation; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; transmembrane receptor protein tyrosine kinase signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	22853
	231876
	ENSG00000164715
	ENSMUSG00000038970
	Q8IWU2
	Q3TYD6
	NM_014916
	NM_001081109
	NP_055731
	NP_001074578
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase LMTK2 also known as Lemur tyrosine kinase 2 (LMTK2) is an enzyme that in humans is encoded by the LMTK2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164715 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038970 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T (Mar 2004). "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling". Genes to Cells. 9 (3): 219–32. doi:10.1111/j.1356-9597.2004.00714.x. PMID 15005709. S2CID 26059849.
^ "Entrez Gene: LMTK2 lemur tyrosine kinase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164715 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038970 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15005709-5] Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T (Mar 2004). "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling". Genes to Cells. 9 (3): 219–32. doi:10.1111/j.1356-9597.2004.00714.x. PMID 15005709. S2CID 26059849.

[entrez-6] "Entrez Gene: LMTK2 lemur tyrosine kinase 2".

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