LNX1

LNX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B76
Identifiers
Aliases	LNX1, LNX, MPDZ, PDZRN2, ligand of numb-protein X 1
External IDs	OMIM: 609732; MGI: 1278335; HomoloGene: 7819; GeneCards: LNX1; OMA:LNX1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	53,701,405 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	74,863,573 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; parotid gland; ; Brodmann area 23; ; endothelial cell; ; Brodmann area 46; ; oral cavity; ; amniotic fluid; ; skin of arm; ; superior frontal gyrus; ; jejunal mucosa;
	Top expressed in
	motor neuron; ; facial motor nucleus; ; substantia nigra; ; vestibular membrane of cochlear duct; ; Paneth cell; ; right ventricle; ; epithelium of stomach; ; lacrimal gland; ; transitional epithelium of urinary bladder; ; anterior horn of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	PDZ domain binding; protein binding; metal ion binding; ubiquitin-protein transferase activity; transferase activity; zinc ion binding;
Cellular component	cytoplasm;
Biological process	protein homooligomerization; protein ubiquitination; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	84708
	16924
	ENSG00000072201
	ENSMUSG00000029228
	Q8TBB1
	O70263
	NM_001126328; NM_032622
NM_001159577; NM_001159578; NM_001159579; NM_001159580; NM_010727;
	NM_001359074
	NP_001119800; NP_116011
NP_001153049; NP_001153050; NP_001153051; NP_001153052; NP_034857;
	NP_001346003
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase LNX is an enzyme that in humans is encoded by the LNX1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072201 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029228 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xie Y, Zhao W, Wang W, Zhao S, Tang R, Ying K, Zhou Z, Mao Y (Apr 2001). "Identification of a human LNX protein containing multiple PDZ domains". Biochemical Genetics. 39 (3–4): 117–26. doi:10.1023/A:1010269908398. PMID 11521506. S2CID 9150813.
^ Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ (Jan 2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation". The EMBO Journal. 21 (1–2): 93–102. doi:10.1093/emboj/21.1.93. PMC 125803. PMID 11782429.
^ "Entrez Gene: LNX1 ligand of numb-protein X 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072201 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029228 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11521506-5] Xie Y, Zhao W, Wang W, Zhao S, Tang R, Ying K, Zhou Z, Mao Y (Apr 2001). "Identification of a human LNX protein containing multiple PDZ domains". Biochemical Genetics. 39 (3–4): 117–26. doi:10.1023/A:1010269908398. PMID 11521506. S2CID 9150813.

[pmid11782429-6] Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ (Jan 2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation". The EMBO Journal. 21 (1–2): 93–102. doi:10.1093/emboj/21.1.93. PMC 125803. PMID 11782429.

[entrez-7] "Entrez Gene: LNX1 ligand of numb-protein X 1".

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