LPAR4

LPAR4
Identifiers
Aliases	LPAR4, GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9, lysophosphatidic acid receptor 4
External IDs	OMIM: 300086; MGI: 1925384; HomoloGene: 3871; GeneCards: LPAR4; OMA:LPAR4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	78,758,714 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	105,977,506 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; buccal mucosa cell; ; tibia; ; testicle; ; gonad; ; ventricular zone; ; cartilage tissue; ; ganglionic eminence; ; muscle of thigh; ; Achilles tendon;
	Top expressed in
	dermis; ; pituitary stalk; ; efferent ductule; ; human fetus; ; primitive streak; ; trigeminal ganglion; ; tongue; ; Gonadal ridge; ; mandibular prominence; ; left lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lysophosphatidic acid binding; signal transducer activity; lipid binding; G protein-coupled receptor activity; lysophosphatidic acid receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; nuclear body; intracellular membrane-bounded organelle;
Biological process	signal transduction; positive regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2846
	78134
	ENSG00000147145
	ENSMUSG00000049929
	Q99677
	Q8BLG2
	NM_001278000; NM_005296
	NM_175271
	NP_001264929; NP_005287
	NP_780480
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 4 also known as LPA₄ is a protein that in humans is encoded by the LPAR4 gene.^[5]^[6]^[7] LPA₄ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147145 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049929 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR23 G protein-coupled receptor 23".
^ Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106–12. doi:10.1006/bbrc.1997.6895. PMID 9223435.
^ O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID 9073069.
^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147145 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049929 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR23 G protein-coupled receptor 23".

[pmid9223435-6] Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106–12. doi:10.1006/bbrc.1997.6895. PMID 9223435.

[pmid9073069-7] O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID 9073069.

[Choi_2010-8] Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

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