LRTOMT

LRTOMT
Identifiers
Aliases	LRTOMT, CFAP111, DFNB63, LRRC51, leucine rich transmembrane and O-methyltransferase domain containing, TOMT, LRRC51-TOMT
External IDs	OMIM: 612414; MGI: 3769724; HomoloGene: 19664; GeneCards: LRTOMT; OMA:LRTOMT - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	72,110,782 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	101,555,566 bp
RNA expression pattern
	Top expressed in
	testicle; ; right testis; ; left testis; ; olfactory zone of nasal mucosa; ; ganglionic eminence; ; stromal cell of endometrium; ; uterine tube; ; islet of Langerhans; ; gonad; ; ventricular zone;
	Top expressed in
	morula; ; embryo; ; granulocyte; ; blastocyst; ; primary oocyte; ; epiblast; ; white adipose tissue; ; placenta; ; ovary; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	methyltransferase activity; transferase activity; O-methyltransferase activity; L-dopa O-methyltransferase activity; catechol O-methyltransferase activity; orcinol O-methyltransferase activity;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; endoplasmic reticulum; cellular component;
Biological process	methylation; hearing; catecholamine metabolic process; neurotransmitter catabolic process; catecholamine catabolic process; auditory receptor cell development; developmental process; dopamine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	220074
	791260
	ENSG00000284922
	ENSMUSG00000078630
	Q8WZ04; Q96E66
	A1Y9I9
	NM_001145308; NM_001145309; NM_001145310
	NM_001081679; NM_001282088
NP_001138779; NP_001138780; NP_001138781; NP_001138782; NP_001192067;
	NP_001258400; NP_001305732; NP_660352; NP_001138779.1; NP_001192067.1; NP_001258400.1; NP_660352.1; NP_001305732.1
	NP_001075148; NP_001269017
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane O-methyltransferase (TOMT) is a protein encoded by the LRTOMT gene in humans. Located on chromosome 11, mutations in LRTOMT are associated with the DFNB63 form of autosomal recessive nonsyndromic hearing loss.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000284922 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000078630 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000284922 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000078630 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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