Lactoferricin | |
---|---|
Identifiers | |
Symbol | N/A |
OPM superfamily | 203 |
OPM protein | 1lfc |
Lactoferricin is an amphipathic, cationic peptide with anti-microbial[1] and anti-cancer[2] properties. It can be generated by the pepsin-mediated digestion of lactoferrin.
Lactoferricin is the most studied AMP derived from milk protein. The complete sequence of lactoferricin corresponds to lactoferrin fragment 17-41 (FKCRRWQWRM KKLGAPSITCVRRAF; LFB0084 Archived 2018-11-03 at the Wayback Machine) and sequences from within this fragment are also antimicrobial. The MilkAMP database contains a total of 111 peptides (natural, synthetic and modified) comprising or derived from the complete lactoferricin.[1] In humans, lactoferricin corresponds to lactoferrin fragment 1-47 but consists of two subunits, namely fragments 1-11 and 12-47 (LFH0009 Archived 2017-01-13 at the Wayback Machine), connected by a disulfide bridge.[3]
Human Lactoferricin and Bovine Lactoferricin are two greatly studied forms of Lactoferricin. These two forms have great sequence differences. Bovine Lactoferricin contains 25 residues, while Human Lactoferricin contains 49 residues.[4] Also, when placed in solution Bovine Lactoferricin forms a β-pleated sheet, while Human Lactoferricin forms a coiled structure.[5]