Lady Frances Radclyffe (died 1602) was an English noblewoman, who early in the reign of Queen Elizabeth I of England became one of her Maids of Honour. It was at the royal court when Frances attracted the attention of visiting Irish chieftain Shane O'Neill, who was searching for a "proper English wife"[1] and made her a proposal of matrimony, which she refused to consider. She later married Sir Thomas Mildmay, by whom she had two sons.