The Lake Superior National Estuarine Research Reserve includes land and water areas along the St. Louis River and Lake Superior in Douglas County, in the northwest corner of Wisconsin, United States. It is one of 29 National Estuarine Research Reserves. The Reserve is operated as a program of the Natural Resources Institute of the University of Wisconsin-Madison Division of Extension. It has an area of 16,697 acres (6,757 ha), and was designated in 2010.[1]