Lanreotide

Lanreotide
Clinical data
Trade names	Somatuline
Other names	Lanreotide acetate (JAN JP), Lanreotide acetate (USAN US)
AHFS/Drugs.com	Monograph
License data	US DailyMed: Lanreotide; US FDA: Lanreotide;
Pregnancy; category	AU: C; ;
Routes of; administration	Intramuscular, subcutaneous
ATC code	H01CB03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	Approximately 80%
Protein binding	78%
Metabolism	In GI tract
Elimination half-life	2 hours (immediate release); 5 days (sustained release)
Excretion	Mostly bile duct
Identifiers
	IUPAC name 3-(2-naphthyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide (2->7)-disulfide;
CAS Number	108736-35-2 ;
PubChem CID	71349;
IUPHAR/BPS	2031;
DrugBank	DB06791;
ChemSpider	64450 ;
UNII	0G3DE8943Y;
KEGG	D04666;
ChEMBL	ChEMBL1201185 ;
CompTox Dashboard (EPA)	DTXSID60897514 ;
ECHA InfoCard	100.215.992
Chemical and physical data
Formula	C54H69N11O10S2
Molar mass	1096.33 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]([C@@H](C(=O)N)NC(=O)[C@@H]1CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C(C)C)CCCCN)Cc2c[nH]c3c2cccc3)Cc4ccc(cc4)O)NC(=O)[C@@H](Cc5ccc6ccccc6c5)N)O;
	InChI InChI=1S/C54H69N11O10S2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74)/t30-,38-,40+,41+,42-,43+,44+,45+,46+/m1/s1 ; Key:PUDHBTGHUJUUFI-SCTWWAJVSA-N ;
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Lanreotide, sold under the brand name Somatuline among others, is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome. It is a long-acting analogue of somatostatin, like octreotide.

Lanreotide (as lanreotide acetate) is manufactured by Ipsen. It is available in several countries, including the United Kingdom, Australia and Canada, and was approved for sale in the United States by the Food and Drug Administration (FDA) on August 30, 2007.^[2]

^ "Mytolac (Amdipharm Mercury Australia Pty Ltd)". Therapeutic Goods Administration (TGA). 28 September 2022. Archived from the original on 13 November 2022. Retrieved 29 April 2023.
^ "FDA Approves New Drug to Treat Rare Disease, Acromegaly" (Press release). U.S. Food and Drug Administration. 30 August 2007. Archived from the original on 10 April 2021. Retrieved 6 September 2007.

[1] "Mytolac (Amdipharm Mercury Australia Pty Ltd)". Therapeutic Goods Administration (TGA). 28 September 2022. Archived from the original on 13 November 2022. Retrieved 29 April 2023.

[2] "FDA Approves New Drug to Treat Rare Disease, Acromegaly" (Press release). U.S. Food and Drug Administration. 30 August 2007. Archived from the original on 10 April 2021. Retrieved 6 September 2007.

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