Lara Mahal

Lara K. Mahal
NationalityAmerican
Alma mater
Known forlectin microarrays in glycomics
miRNA regulation of glycosylation
unnatural carbohydrate incorporation
Children2
AwardsCERC in Glycomics (2019-)

Horace Isbell Award in Carbohydrate Chemistry (2017) NIH Director New Innovator Award (2008) Sloan Foundation Fellowship (2008) NSF CAREER Award (2007) Beckman Young Investigator (2004) Jane Coffin Childs Postdoctoral Fellow (2000) ACS Medicinal Chemistry Predoctoral Fellow (1998)

UC Regents Scholar (1993)
Scientific career
Institutions
ThesisBiosynthetic modulation of cell surface sialosides (2000)
Doctoral advisorCarolyn Bertozzi

Lara K. Mahal is an American chemist who is the Canada Excellence Research Chair in Glycomics at the University of Alberta in Edmonton, Alberta, Canada.[1] She is also a Professor of Chemistry at the University of Alberta.[2] She is notable both for her pioneering work establishing lectin microarrays as a new technology for glycomics,[3][4] her work on miRNA regulation of glycosylation [5][6][7][8] and her graduate work with Carolyn R. Bertozzi on unnatural carbohydrate incorporation.[9] Work in her laboratory focuses on understanding the role of carbohydrates in human health using systems- and chemical biology-based approaches[10]

  1. ^ Chairs, Canada Excellence Research (2012-11-29). "Canada Excellence Research Chairs". www.cerc.gc.ca. Retrieved 2020-09-09.
  2. ^ "Faculty | Chemistry".
  3. ^ Pilobello, K.T.; Slawek, D.; Mahal, L.K. A ratiometric lectin microarray approach to analysis of the dynamic mammalian glycome, Proc. Natl. Acad. Sci., USA, 2007, 104, 10534-10539.
  4. ^ Krishnamoorthy L.; Mahal L.K. Glycomic analysis: an array of technologies. ACS Chem Biol. 2009, 4, 715-732.
  5. ^ Agrawal, P.; Kurcon, T.; Pilobello, K.T.; Rakus, J.F.; Koppolu, S.; Liu, Z.; Batista, B.S.; Eng, W.S., Hsu, K.-L.; Liang, Y.; Mahal, L.K. Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode. Proc. Natl. Acad. Sci., USA, 2014, 111, 4338-43. doi: 10.1073/pnas.1321524111
  6. ^ Kasper, B.T.; Koppolu, S.; Mahal, L.K. Insights into MiRNA Regulation of the Human Glycome. Biochem. Biophys. Res. Commun. 2014, 445, 774-9. doi: 10.1016/j.bbrc.2014.01.034.
  7. ^ Kurcon, T.; Liu, Z.; Paradkar, A.V.; Vaiana, C.A.; Koppolu, S.; Agrawal, P.; Mahal, L.K. miRNA proxy approach reveals hidden functions of glycosylation. Proc. Natl. Acad. Sci., USA, 2015, 112, 7327-32. doi: 10.1073/pnas.1502076112.
  8. ^ Vaiana, C.A.; Kurcon, T.; Mahal, L.K. MicroRNA-424 Predicts a Role for β-1,4 Branched Glycosylation in Cell Cycle Progression. J. Biol. Chem., 2016, 291, 1529-37. doi: 10.1074/jbc.M115.672220.
  9. ^ Mahal, L.K.; Yarema, K.J.; Bertozzi, C.R. Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis. Science 1997, 276, 1125-1128.
  10. ^ "Home". glycocode.org.