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| Location | Moscow, Russia |
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| Coordinates | 55°45′40″N 37°42′22″E / 55.7611407°N 37.7062039°E |
| Status | operational |
| Security class | detention center |
| Opened | 1881 |
| Managed by | Ministry of Justice of the RF |
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Lefortovo Prison (Russian: Лефортовская тюрьма, IPA: [lʲɪˈfortəvə] ) is a prison in Moscow, Russia, which has been under the jurisdiction of the Russian Ministry of Justice since 2005.