Leptin receptor

LEPR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLEPR, CD295, LEP-R, LEPRD, OB-R, OBR, leptin receptor
External IDsOMIM: 601007; MGI: 104993; HomoloGene: 1731; GeneCards: LEPR; OMA:LEPR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001122899
NM_010704
NM_146146

RefSeq (protein)

NP_001116371
NP_034834
NP_666258

Location (UCSC)Chr 1: 65.42 – 65.64 MbChr 4: 101.57 – 101.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor,[5] a protein that in humans is encoded by the LEPR gene.[6][7] LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 (cluster of differentiation 295). Its location is the cell membrane, and it has extracellular, trans-membrane and intracellular sections (protein regions).

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116678Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057722Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cirillo D, Rachiglio AM, la Montagna R, Giordano A, Normanno N (November 2008). "Leptin signaling in breast cancer: an overview". Journal of Cellular Biochemistry. 105 (4): 956–64. doi:10.1002/jcb.21911. PMID 18821585. S2CID 25572220.
  6. ^ Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, et al. (December 1995). "Identification and expression cloning of a leptin receptor, OB-R". Cell. 83 (7): 1263–71. doi:10.1016/0092-8674(95)90151-5. PMID 8548812.
  7. ^ Winick JD, Stoffel M, Friedman JM (August 1996). "Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1". Genomics. 36 (1): 221–2. doi:10.1006/geno.1996.0455. PMID 8812446.