Leucyl-tRNA synthetase

LARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WFD
Identifiers
Aliases	LARS1, Leucyl-tRNA synthetase, ILFS1, HSPC192, LARS, leucyl-tRNA synthetase 1, LRS, LEUS, LFIS, PIG44, hr025Cl, LEURS, RNTLS
External IDs	OMIM: 151350; MGI: 1913808; HomoloGene: 7083; GeneCards: LARS1; OMA:LARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	146,182,696 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	42,395,259 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; ventricular zone; ; middle temporal gyrus; ; body of pancreas; ; right uterine tube; ; ganglionic eminence; ; primary visual cortex; ; cartilage tissue; ; islet of Langerhans;
	Top expressed in
	medullary collecting duct; ; basilar part of occipital bone; ; lacrimal gland; ; yolk sac; ; primitive streak; ; renal corpuscle; ; calvaria; ; seminal vesicula; ; ureter; ; salivary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; leucine-tRNA ligase activity; ligase activity; protein binding; ATP binding; aminoacyl-tRNA editing activity; valine-tRNA ligase activity; GTPase activator activity; glutamine-tRNA ligase activity;
Cellular component	cytosol; nuclear body; cytoplasm; lysosome; endoplasmic reticulum; endomembrane system; aminoacyl-tRNA synthetase multienzyme complex;
Biological process	tRNA aminoacylation for protein translation; protein biosynthesis; leucyl-tRNA aminoacylation; valyl-tRNA aminoacylation; protein targeting to lysosome; regulation of cell size; negative regulation of autophagy; cellular response to amino acid starvation; positive regulation of GTPase activity; cellular response to amino acid stimulus; cellular response to leucine; positive regulation of TORC1 signaling; cellular response to leucine starvation; glutaminyl-tRNA aminoacylation; aminoacyl-tRNA metabolism involved in translational fidelity;
	Sources:Amigo / QuickGO
Orthologs
	51520
	107045
	ENSG00000133706
	ENSMUSG00000024493
	Q9P2J5
	Q8BMJ2
	NM_020117; NM_001317964; NM_001317965; NM_016460
	NM_134137
	NP_001304893; NP_001304894; NP_057544; NP_064502
	NP_598898
	Wikidata
View/Edit Human	View/Edit Mouse

Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133706 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024493 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Giles RE, Shimizu N, Ruddle FH (September 1980). "Assignment of a human genetic locus to chromosome 5 which corrects the heat sensitive lesion associated with reduced leucyl-tRNA synthetase activity in ts025Cl Chinese hamster cells". Somatic Cell Genetics. 6 (5): 667–687. doi:10.1007/BF01538645. PMID 6933703. S2CID 11128003.
^ "Entrez Gene: LARS leucyl-tRNA synthetase".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133706 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024493 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6933703-5] Giles RE, Shimizu N, Ruddle FH (September 1980). "Assignment of a human genetic locus to chromosome 5 which corrects the heat sensitive lesion associated with reduced leucyl-tRNA synthetase activity in ts025Cl Chinese hamster cells". Somatic Cell Genetics. 6 (5): 667–687. doi:10.1007/BF01538645. PMID 6933703. S2CID 11128003.

[entrez-6] "Entrez Gene: LARS leucyl-tRNA synthetase".

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