Leukotriene C4 synthase

LTC4S
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JRZ, 2PNO, 2UUH, 2UUI, 3B29, 3HKK, 3LEO, 3PCV, 4J7T, 4J7Y, 4JC7, 4JCZ, 5HV9, 4WAB
Identifiers
Aliases	LTC4S, entrez:4056, Leukotriene C4 synthase
External IDs	OMIM: 246530; MGI: 107498; HomoloGene: 7406; GeneCards: LTC4S; OMA:LTC4S - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	179,796,647 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,129,443 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; testicle; ; apex of heart; ; right coronary artery; ; left uterine tube; ; right auricle; ; left coronary artery; ; right adrenal cortex; ; olfactory zone of nasal mucosa; ; right hemisphere of cerebellum;
	Top expressed in
	choroid plexus of fourth ventricle; ; lactiferous gland; ; white adipose tissue; ; subcutaneous adipose tissue; ; brown adipose tissue; ; stroma of bone marrow; ; right kidney; ; embryo; ; primary oocyte; ; Epithelium of choroid plexus;
	More reference expression data
	n/a
Gene ontology
Molecular function	leukotriene-C4 synthase activity; glutathione peroxidase activity; protein binding; lyase activity; enzyme activator activity; lipid binding; identical protein binding; glutathione transferase activity;
Cellular component	integral component of membrane; membrane; nuclear envelope; endoplasmic reticulum; nuclear outer membrane; nucleus; intracellular membrane-bounded organelle; endoplasmic reticulum membrane;
Biological process	positive regulation of catalytic activity; leukotriene biosynthetic process; cellular oxidant detoxification; leukotriene metabolic process; long-chain fatty acid biosynthetic process; lipoxygenase pathway; lipoxin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4056
	17001
	ENSG00000283887; ENSG00000213316
	ENSMUSG00000020377
	Q16873
	Q60860
	NM_145867; NM_000897
	NM_008521; NM_001313968
	NP_665874
	NP_001300897; NP_032547
	Wikidata
View/Edit Human	View/Edit Mouse

Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene.^[5]^[6]

The protein encoded by this gene, LTC4S (or glutathione S-transferase II) is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4. This is a member of MAPEG family of transmembrane proteins. A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum, where it forms a complex with 5-Lipoxygenase-activating protein. This protein is remotely related to microsomal glutathione S-transferase.

^ ^a ^b ^c ENSG00000213316 GRCh38: Ensembl release 89: ENSG00000283887, ENSG00000213316 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020377 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lam BK, Penrose JF, Freeman GJ, Austen KF (Sep 1994). "Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4". Proc Natl Acad Sci U S A. 91 (16): 7663–7. Bibcode:1994PNAS...91.7663L. doi:10.1073/pnas.91.16.7663. PMC 44462. PMID 8052639.
^ "Entrez Gene: LTC4S leukotriene C4 synthase".

[refGRCh38Ensembl-1] ENSG00000213316 GRCh38: Ensembl release 89: ENSG00000283887, ENSG00000213316 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020377 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8052639-5] Lam BK, Penrose JF, Freeman GJ, Austen KF (Sep 1994). "Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4". Proc Natl Acad Sci U S A. 91 (16): 7663–7. Bibcode:1994PNAS...91.7663L. doi:10.1073/pnas.91.16.7663. PMC 44462. PMID 8052639.

[entrez-6] "Entrez Gene: LTC4S leukotriene C4 synthase".

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