Levobunolol

Levobunolol
Clinical data
Trade namesAKBeta, Betagan, Vistagan, others
AHFS/Drugs.comMonograph
MedlinePlusa686011
Pregnancy
category
  • C
Routes of
administration		Topical eye drop
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability7.5% (rabbit eye)
Metabolitesdihydrolevobunolol (equally active)
Onset of action≤ 1 hour
Elimination half-life6 hours[2]
Duration of actionup to 16 hours
Excretionmostly renal
Identifiers
  • (S)-5-{[3-(tert-Butylamino)-2-hydroxypropyl]oxy}-3,4-dihydronaphthalen-1(2H)-one
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H25NO3
Molar mass291.391 g·mol−1
3D model (JSmol)
Melting point209 to 211 °C (408 to 412 °F) (hydrochloride)
Solubility in watersoluble (hydrochloride)
  • O=C2c1cccc(OC[C@@H](O)CNC(C)(C)C)c1CCC2
  • InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1 checkY
  • Key:IXHBTMCLRNMKHZ-LBPRGKRZSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Levobunolol (trade names AKBeta, Betagan, Vistagan, among others) is a non-selective beta blocker. It is used topically in the form of eye drops to manage ocular hypertension (high pressure in the eye) and open-angle glaucoma.[3]

  1. ^ "Archived copy" (PDF). Archived (PDF) from the original on 2022-09-06. Retrieved 2022-09-06.{{cite web}}: CS1 maint: archived copy as title (link)
  2. ^ Cite error: The named reference Arzneistoff-Profile was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference AustriaCodex was invoked but never defined (see the help page).