Lewis and Clark Bridge may refer to:
- Lewis and Clark Bridge (Wolf Point, Montana), bridge spanning the Missouri River built in 1930
- Lewis and Clark Bridge (Columbia River), bridge spanning the Columbia River between Oregon and Washington states
- Lewis and Clark Bridge (Ohio River), connecting the eastern part of Louisville, Kentucky to Clark County, Indiana
- Lewis and Clark River Bridge, bridge spanning the Lewis and Clark River, in Clatsop County, Oregon
- Lewis and Clark Viaduct or Intercity Viaduct, automobile and pedestrian crossing of the Kansas River in the United States