Liothyronine

This article is about liothyronine as a medication. For the hormone, see Triiodothyronine.

Liothyronine
Clinical data
Trade namesCytomel, Tertroxin, others
AHFS/Drugs.comMonograph
MedlinePlusa682462
License data
Routes of
administration		By mouth, intravenous
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
Protein binding99.7%
Elimination half-life2.5 days
Identifiers
  • sodium (S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.000.203 Edit this at Wikidata
Chemical and physical data
FormulaC15H11I3NNaO4
Molar mass672.959 g·mol−1
3D model (JSmol)
  • [Na+].[O-]C(=O)[C@@H](N)Cc2cc(I)c(Oc1cc(I)c(O)cc1)c(I)c2.O
  • InChI=1S/C15H12I3NO4.Na.H2O/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;;/h1-4,6,12,20H,5,19H2,(H,21,22);;1H2/q;+1;/p-1/t12-;;/m0../s1 checkY
  • Key:IRGJMZGKFAPCCR-LTCKWSDVSA-M checkY
 ☒NcheckY (what is this?)  (verify)

Liothyronine is a manufactured form of the thyroid hormone triiodothyronine (T3).[1] It is most commonly used to treat hypothyroidism and myxedema coma.[1] It can be taken by mouth or by injection into a vein.[1]

Side effects may occur from excessive doses.[1] This may include weight loss, fever, headache, anxiety, trouble sleeping, arrhythmias, and heart failure.[1] Use in pregnancy and breastfeeding is generally safe.[2][1] Regular blood tests are recommended to verify the appropriateness of the dose being taken.[1]

Liothyronine was approved for medical use in 1956.[1] It is available as a generic medication.[2] In 2022, it was the 204th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[3][4]

  1. ^ a b c d e f g h "Liothyronine Sodium Monograph for Professionals". Drugs.com. Retrieved 27 February 2019.
  2. ^ a b British National Formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 757. ISBN 9780857113382.
  3. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  4. ^ "Liothyronine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.