| Lipase inhibitor | |
|---|---|
| Drug class | |
 Chemical structure of the lipase inhibitor Orlistat | |
| Class identifiers | |
| ATC code | A08AB |
| Mode of action | Inhibits gastric lipase and pancreatic lipase |
| Legal status | |
| In Wikidata | |
Lipase inhibitors are substances used to reduce the activity of lipases found in the intestine. Lipases are secreted by the pancreas when fat is present. The primary role of lipase inhibitors is to decrease the gastrointestinal absorption of fats. Fats then tend to be excreted in feces rather than being absorbed to be used as a source of caloric energy, and this can result in weight loss in individuals.[1] These inhibitors could be used for the treatment of obesity, which can subsequently lead to Type 2 diabetes and cardiovascular diseases if not managed. An example of a lipase inhibitor is orlistat.[2]
- ^ Aronne, Louis. "Treating Obesity:Drug Treatment for Obesity". Treating Obesity. Medscape News. Retrieved March 22, 2012.
- ^ Franson, K.; Rossner (2000). "Fat intake and food choices during weight reduction with diet, behavioural modification and a lipase inhibitor". Journal of Internal Medicine. 247 (5): 607–614. doi:10.1046/j.1365-2796.2000.t01-1-00666.x. PMID 10810001.