Mammalian protein found in Homo sapiens
Lipoprotein lipase (LPL ) (EC 3.1.1.34, systematic name triacylglycerol acylhydrolase (lipoprotein-dependent )) is a member of the lipase gene family, which includes pancreatic lipase , hepatic lipase , and endothelial lipase . It is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins , such as those found in chylomicrons and very low-density lipoproteins (VLDL) , into two free fatty acids and one monoacylglycerol molecule:
triacylglycerol + H2 O = diacylglycerol + a carboxylate
It is also involved in promoting the cellular uptake of chylomicron remnants , cholesterol-rich lipoproteins, and free fatty acids.[ 5] [ 6] [ 7] LPL requires ApoC-II as a cofactor.[ 8] [ 9]
LPL is attached to the luminal surface of endothelial cells in capillaries by the protein glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1 ) and by heparan sulfated peptidoglycans.[ 10] It is most widely distributed in adipose, heart, and skeletal muscle tissue, as well as in lactating mammary glands.[ 11] [ 12] [ 13]
^ a b c GRCh38: Ensembl release 89: ENSG00000175445 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015568 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Cite error: The named reference Mead-2002
was invoked but never defined (see the help page ).
^ Rinninger F, Kaiser T, Mann WA, Meyer N, Greten H, Beisiegel U (July 1998). "Lipoprotein lipase mediates an increase in the selective uptake of high density lipoprotein-associated cholesteryl esters by hepatic cells in culture" . J. Lipid Res . 39 (7): 1335–48. doi :10.1016/S0022-2275(20)32514-1 . PMID 9684736 .
^ Ma Y, Henderson HE, Liu MS, Zhang H, Forsythe IJ, Clarke-Lewis I, Hayden MR, Brunzell JD (November 1994). "Mutagenesis in four candidate heparin binding regions (residues 279-282, 291-304, 390-393, and 439-448) and identification of residues affecting heparin binding of human lipoprotein lipase" . J. Lipid Res . 35 (11): 2049–59. doi :10.1016/S0022-2275(20)39951-X . PMID 7868983 .
^ Kim SY, Park SM, Lee ST (January 2006). "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. Biophys. Res. Commun . 339 (1): 47–54. doi :10.1016/j.bbrc.2005.10.182 . PMID 16314153 .
^ Kinnunen PK, Jackson RL, Smith LC, Gotto AM, Sparrow JT (November 1977). "Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II" . Proc. Natl. Acad. Sci. U.S.A . 74 (11): 4848–51. Bibcode :1977PNAS...74.4848K . doi :10.1073/pnas.74.11.4848 . PMC 432053 . PMID 270715 .
^ Meneghetti MC, Hughes AJ, Rudd TR, Nader HB, Powell AK, Yates EA, Lima MA (September 2015). "Heparan sulfate and heparin interactions with proteins" . Journal of the Royal Society, Interface . 12 (110): 0589. doi :10.1098/rsif.2015.0589 . PMC 4614469 . PMID 26289657 .
^ Wang CS, Hartsuck J, McConathy WJ (January 1992). "Structure and functional properties of lipoprotein lipase" (PDF) . Biochimica et Biophysica Acta . 1123 (1): 1–17. doi :10.1016/0005-2728(92)90119-M . PMID 1730040 .
^ Wong H, Schotz MC (July 2002). "The lipase gene family" . Journal of Lipid Research . 43 (7): 993–9. doi :10.1194/jlr.R200007-JLR200 . PMID 12091482 .
^ Braun JE, Severson DL (October 1992). "Regulation of the synthesis, processing and translocation of lipoprotein lipase" . The Biochemical Journal . 287 ( Pt 2) (2): 337–47. doi :10.1042/bj2870337 . PMC 1133170 . PMID 1445192 .