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| Liquid breathing | |
|---|---|
 Computer-generated model of perflubron and gentamicin molecules in liquid suspension for pulmonary administration | |
| MeSH | D021061 |
Liquid breathing is a form of respiration in which a normally air-breathing organism breathes an oxygen-rich liquid which is capable of CO2 gas exchange (such as a perfluorocarbon).[1]
The liquid involved requires certain physical properties, such as respiratory gas solubility, density, viscosity, vapor pressure and lipid solubility, which some perfluorochemicals (PFCs) have.[2] Thus, it is critical to choose the appropriate PFC for a specific biomedical application, such as liquid ventilation, drug delivery or blood substitutes. The physical properties of PFC liquids vary substantially; however, the one common property is their high solubility for respiratory gases. In fact, these liquids carry more oxygen and carbon dioxide than blood.[3]
In theory, liquid breathing could assist in the treatment of patients with severe pulmonary or cardiac trauma, especially in pediatric cases.[how?] Liquid breathing has also been proposed for use in deep diving[4][5][6] and space travel.[7][8] Despite some recent advances in liquid ventilation, a standard mode of application has not yet been established.
- ^ GAEDEKE NORMS, M., RN, MSN, CCRN, CS, et al. Liquid Ventilation: It's Not Science Fiction Anymore. AACN Clin Issues Crit Care Nurs. 1994;5(3):246-254. Cited in: Your Journals@Ovid.
- ^ Shaffer, Thomas H.; Wolfson, Marla R.; Clark, Leland C. (Oct 1992). "Liquid ventilation". Pediatric Pulmonology. 14 (2): 102–109. doi:10.1002/ppul.1950140208. PMID 1437347. S2CID 222167378.
- ^ Gabriel, Jerome L.; Miller, T. F.; Wolfson, Marla R.; Shaffer, Thomas H. (Nov 1996). "Quantitative Structure-Activity Relationships of Perfluorinated Hetero-Hydrocarbons as Potential Respiratory Media: Application to Oxygen Solubility, Partition Coefficient, Viscosity, Vapor Pressure, and Density". ASAIO Journal. 42 (6): 968–973. doi:10.1097/00002480-199642060-00009. ISSN 1058-2916. PMID 8959271. S2CID 31161098.
- ^ Kylstra JA (1977). The Feasibility of Liquid Breathing in Man. Vol. Report to the US Office of Naval Research. Durham, NC: Duke University. Archived from the original on 2008-07-07. Retrieved 2008-05-05.
{{cite book}}: CS1 maint: unfit URL (link) - ^ "menfish". Archived from the original on 2008-05-16. Retrieved 2008-05-17.
- ^ Featured on the ABC television program That's Incredible, including a demonstration of a mouse surviving a prolonged dunking in perfluorocarbon.
- ^ "Liquid Breathing - Medical uses". Archived from the original on 2010-04-15. Retrieved 2008-05-17.
- ^ Featured on the ABC television program That's Incredible. Cathy Lee Crosby describing diving and spaceflight applications. Voiceover with stock video.