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Top row: Black Star, Tsubaki Nakatsukasa, Soul Eater Evans, and Maka Albarn.
Bottom row: Liz and Patty Thompson, Death the Kid, Blair, and Spirit Albarn.
The Soul Eater manga and anime series features an extensive cast of fictional characters created by Atsushi Ohkubo. It is set in a fictional universe inhabited by various characters capable of using supernatural powers by channeling the wavelengths of their souls. Most of the characters in the series, including the main protagonists, are classified into two groups: humans who are born with the power to turn into weapons, called "demon weapons", and the wielders of these weapons, called "meisters". The main protagonists attend a school called Death Weapon Meister Academy (DWMA) located in the fictional Death City in Nevada, United States. DWMA is run by Shinigami, also known as Death, or the Grim Reaper, as a training facility for weapons and meisters to hone their powers, as well as an organization to preserve world order against anyone who threatens it, including witches, monsters and kishin, which are essentially humans who become monstrous creatures by devouring the souls of innocent people.
The main Soul Eater manga and its anime adaptation follow three meister/weapon partnerships—Maka Albarn and her scythe, Soul Eater; Black Star and his shadow weapon[broken anchor], Tsubaki Nakatsukasa; and Death the Kid and his twin pistols, Liz and Patty Thompson. These three teams and their fellow students act as field agents for their school, reaping the souls of evil humans to prevent them from turning into kishin. The spin-off prequel manga titled Soul Eater Not!, also created by Ohkubo, follows the everyday lives of three other DWMA students—halberd Tsugumi Harudori and her two meister friends, Meme Tatane and Anya Hepburn.