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The Grudge film series features a large cast of characters mainly created by screenwriter Stephen Susco and Takashi Shimizu. The film series focuses on people affected by a deadly curse that spreads like a virus and manifests itself in various ways, such as turning people homicidal or people being haunted, ultimately leading to their demise if they come in contact with the curse in any way.
All films in the series feature different protagonists, with the first being Karen Davis played by Sarah Michelle Gellar. The protagonist of the second installment and Karen's younger sister Aubrey was played by Amber Tamblyn, while the protagonist of The Grudge 3, Lisa, was portrayed by Johanna Braddy.