The Tokyo Mew Mew manga and anime series features a cast of characters designed by Mia Ikumi. The series takes place in Tokyo, Japan, where five adolescent girls, called Mew Mews, are infused with the DNA of endangered species to combat aliens attempting to take over the Earth. The manga series is followed by a short sequel series, Tokyo Mew Mew a la Mode, which introduces a new Mew Mew and a new threat.
The Mew Mews are led by the main character, Ichigo Momomiya, whose first task is to gather the other four Mew Mews: Minto Aizawa, Retasu Midorikawa, Bu-Ling Huang, and Zakuro Fujiwara. As the series progresses, Ichigo goes from having a crush on Masaya Aoyama to becoming his girlfriend while trying to hide her secret double life from him. The series antagonists include three aliens, Quiche, Pie, and Tart, and their leader, Deep Blue. Originally from Earth, the aliens were forced to leave long ago due to deadly environmental changes. They have returned to kill the humans, who they feel are destroying their planet, and reclaim the planet. In a la Mode, middle school student Berry Shirayuki is introduced as the sixth Mew Mew and, in the absence of Ichigo, the temporary leader of the Mew Mews. A la Mode also introduces new set of antagonists, the Saint Rose Crusaders, a group of human teenagers with various psychic abilities with a desire to create their own utopia. Led by Duke, they make several attempts to kill Berry, eventually turning the local populace against the Mew Mews.
Ikumi's initial vision for Tokyo Mew Mew was a story called Tokyo Black Cat Girl that featured a cat-girl battling alien invaders. After the story was transitioned to a more upbeat story of five female superhumans, the character designs were redone to have a lighter, more colorful feel. The main series characters were praised for being a perfect fit for the overall story, as well as for their cute appearances. The characters introduced in a la Mode were also praised for their visual appearances, but criticized as being repeats of the original series.