Following is a list of notable defunct restaurants in Portland, Oregon:
- Acadia: A New Orleans Bistro
- Alexis Restaurant (1980–2016)
- Altabira City Tavern (2015–2020)
- Analog Café and Theater
- Arleta Library Bakery & Cafe
- Ataula (2013–2021)
- Aviary (2011–2020)
- Aviv (2017–2021)
- Baby Blue Pizza (2019–2022)
- Backspace
- Bailey's Taproom (2007–2021)
- Batterfish
- Beaker & Flask
- Beast (2007–2020)
- Berbati's Pan
- Berlin Inn (1992–2013)
- Bijou Cafe
- Bistro Agnes (2018–2022)
- Bit House Saloon (2015–2021)
- Biwa (2007–2018)
- Bluehour (2000–2020)
- Blueplate Lunch Counter and Soda Fountain (2006–2016)
- Bombay Cricket Club
- Botanist House (2018–2021)
- Brasserie Montmartre (1978–2006; 2009–2011; 2012–2015)
- Bridges Cafe (late 1990s – 2020)
- British Overseas Restaurant Corporation, formerly Saffron Colonial (2016–2019)
- Byways Cafe (1999–2019)
- Câche Câche
- Cafe Azul
- Caffe Mingo
- Candlelight Cafe & Bar (1984–2012)
- Canlis
- Carriage Room
- Castagna
- Century Bar (2016)
- Chez Machin (later Frog & Snail)
- Cicoria
- Circa 33 (2010–2021)
- Clyde Common (2007–2022)
- Country Bill's (1964–2012)
- Cup & Saucer Cafe (1980s–2022)
- Davis Street Tavern (2008–2016)
- Der Rheinlander (1963–2017)
- Dick's Kitchen (2010)
- Dig a Pony (2011–2022)
- Dime Store (2014–2015)
- Dóttir (2019–2022)
- Egyptian Club
- El Gallo Taqueria (2009–2022)
- Esparza's (1990–2014)
- Everybody Eats PDX
- Evoe
- Fat Head's Brewery
- Fenouil (2005–2011)
- Fermenter (2019–2024)
- Fish Grotto
- Fong Chong
- Genoa
- Georgian Room
- Gilt Club (2005–2014)
- The Goose
- Gotham Tavern
- Greek Cusina
- Grüner (2009–2015)
- Gypsy Restaurant and Velvet Lounge (1947–2014)
- Handsome Pizza (2012–2022)
- Henry Ford's Restaurant
- Henry Thiele Restaurant (1932–1990s)
- Hobo's
- Holy Trinity Barbecue (2019–2021)
- House of Louie
- Hunan Restaurant (1979–2014)
- Hung Far Low (1928–2015)
- Industrial Cafe and Saloon
- Irving Street Kitchen (2010–2020)
- Isabel Pearl
- JaCiva's Bakery and Chocolatier (1986–2024)
- Jackknife Bar (2014–2020)
- Kenny & Zuke's Delicatessen
- Kornblatt's Delicatessen (1991–2023)
- La Carreta Mexican Restaurant (1990–2020s)
- La Moule
- Lazy Susan (2020–2023)
- Le Bistro Montage
- Lincoln Restaurant (2008–2017)
- The Liquor Store (2015–2020)
- Little Bird Bistro (2010–2019)
- Local Lounge (2010–2021)
- Lonesome's Pizza (2010–2017)
- Lovely Hula Hands (2003–2009)
- Lucier (2008)
- Malka (2020–2023)
- Mama Đút (2020–2023)
- Masia
- The Matador (1971–2014)
- Metrovino
- Mi Mero Mole (2011–2020)
- Ned Ludd
- Nel Centro (2009–2020)
- New Copper Penny
- No Vacancy Lounge
- NOLA Doughnuts
- Ocean City Seafood Restaurant (2009–2020s)
- Olympia Provisions Public House
- Organ Grinder Restaurant
- Original Taco House (1960–2017)
- Overlook Restaurant (1974–2018)
- The Pagoda (1940–2008)
- Paley's Place (1995–2021)
- Paragon
- The Parish (2012–2016)
- Pazzo Ristorante
- PDX671
- Pearl Tavern (2016–2018)
- Phở Gabo
- Pied Cow Coffeehouse
- Ping (2009–2012; 2020–2021)
- Pink Feather (1957–2017)
- Pok Pok (2005–2020)
- Portland Penny Diner (2012–2017)
- Portobello Vegan Trattoria (2008–2016)
- Purrington's Cat Lounge
- The Queen's Head (2021–2022)
- Radar (2012–2022)
- Raven & Rose
- Red and Black Cafe (2000–2015)
- Revelry (2016–2020)
- RingSide Fish House (2011–2018)
- Ripe Cooperative
- Roman Candle (2013–2018)
- Roost
- The Roxy (1994–2022)
- Santa Fe Taqueria (1990–2024)
- Satyricon
- Saucebox (1995–2020)
- Seastar Bakery
- Shift Drinks (2015–2020)
- Shine Distillery and Grill (2019–2023)
- Shizuku by Chef Naoko
- Shut Up and Eat
- Southeast Grind (2009–2019)
- Stacked Sandwich Shop (2017–2021; 2023)
- Stanich's
- Starky's (1984–2015)
- The Sudra
- Sunshine Noodles (2019–2022)
- Sunshine Tavern (2011–2017)
- SuperBite
- Sweet Hereafter (2011–2024)
- Sweet Lorraine's (2021–2024)
- Tails & Trotters
- Tanuki
- Tapalaya (2008–2019)
- Tasty n Alder (2013–2020)
- Tasty n Daughters (2019–2020)
- Tasty n Sons (–2019)
- Tercet
- There Be Monsters
- Three Sisters Tavern (1964–2004)
- Tilt (2012)
- Toki
- Toro Bravo (2007–2020)
- Touché Restaurant & Bar (1995–2017)
- Vault Cocktail Lounge
- Veritable Quandary (1971–2016)
- Via Tribunali
- Victory Bar (c. 2006–2019)
- Whiskey Soda Lounge
- Wildwood (1994–2014)
- Wong's King (2004–2020)
- The Woodsman Tavern (2011–2018; 2021–2023)
- Xico (2012–2023)
- Yaw's Top Notch
- Yonder (2019–2022)
- Zefiro (1990–2000)