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This is a list of the men who have served in the capacity of Minister-President or equivalent office in the states within the region of Mecklenburg from the 18th century to 1952. The states in question were Duchy and Grand Duchy of Mecklenburg-Schwerin, Duchy and Grand Duchy of Mecklenburg-Strelitz, Free States of Mecklenburg-Schwerin and Mecklenburg-Strelitz and unified state of Mecklenburg.
In 1990, with German reunification, the state was re-established as Mecklenburg-Vorpommern.