Lyme Handley is a former civil parish in Cheshire East, England. It contained 32 buildings that are recorded in the National Heritage List for England as designated listed buildings. Of these, one is listed at Grade I, the highest grade, three are listed at Grade II*, the middle grade, and the others are at Grade II. The major building in the parish is the mansion of Lyme Park. Its estate, which contains a number of listed buildings, occupies much of the parish. The parish was entirely rural, and most of the other listed buildings are farmhouses or farm buildings. In addition the list includes two bridges, an ancient standing stone, and a milestone.