Middleton-by-Wirksworth is a civil parish in the Derbyshire Dales district of Derbyshire, England. The parish contains six listed buildings that are recorded in the National Heritage List for England. All the listed buildings are designated at Grade II, the lowest of the three grades, which is applied to "buildings of national importance and special interest".[1] The parish contains the village of Middleton-by-Wirksworth and the surrounding area, and the listed buildings consist of houses, cottages and associated structures, a milestone and a church.