Little Italy is a general name for an ethnic enclave populated primarily by Italians or people of Italian ancestry, usually in an urban neighborhood.
Little Italy may also refer to:
- Little Italy (1921 film), an American comedy film directed by George Terwilliger and written by Tom McNamara and Peter Milne
- Little Italy (1978 film), an Italian "poliziottesco"-comedy film directed by Bruno Corbucci and the fourth chapter in the Nico Giraldi film series
- Little Italy (2018 film), an English-language romantic comedy film starring Emma Roberts and Hayden Christensen