Live attenuated influenza vaccine

Live attenuated influenza vaccine
Nurse administering the FluMist product
Vaccine description
TargetInfluenza
Vaccine typeAttenuated
Clinical data
Trade namesFlumist, Flumist Quadrivalent, Fluenz Tetra
AHFS/Drugs.comMonograph
License data
Routes of
administration		Intranasal
ATC code
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
  • none
KEGG
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Live attenuated influenza vaccine (LAIV) is a type of influenza vaccine in the form of a nasal spray that is recommended for the prevention of influenza.[2][7]

It is an attenuated live vaccine, unlike other influenza vaccines, which are inactivated vaccines. Live attenuated influenza vaccine is administered intranasally,[8] while inactivated vaccines are administered by intramuscular injection. Live attenuated influenza vaccine is sold under the brand names FluMist and FluMist Quadrivalent in the United States; and the brand name Fluenz Tetra in the European Union.[4][6] FluMist was first introduced in 2003 by MedImmune.[9][10][11]

In the United States, FluMist is approved for self- or caregiver-administration.[12][13] It is the first influenza vaccine that does not need to be administered by a health care provider.[12]

  1. ^ "Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
  2. ^ a b "Flumist- influenza vaccine live intranasal spray". DailyMed. 6 August 2024. Retrieved 21 September 2024.
  3. ^ Cite error: The named reference FDA Flumist was invoked but never defined (see the help page).
  4. ^ a b "FluMist Quadrivalent". U.S. Food and Drug Administration (FDA). 15 November 2019. STN 125020. Archived from the original on 28 November 2019. Retrieved 28 November 2019.
  5. ^ Cite error: The named reference Fluenz EPAR was invoked but never defined (see the help page).
  6. ^ a b "Fluenz Tetra EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 28 November 2019. Retrieved 27 November 2019.
  7. ^ Block SL, Yogev R, Hayden FG, Ambrose CS, Zeng W, Walker RE (September 2008). "Shedding and immunogenicity of live attenuated influenza vaccine virus in subjects 5-49 years of age". Vaccine. 26 (38): 4940–4946. doi:10.1016/j.vaccine.2008.07.013. PMID 18662737.
  8. ^ Belshe RB, Edwards KM, Vesikari T, Black SV, Walker RE, Hultquist M, et al. (CAIV-T Comparative Efficacy Study Group) (February 2007). "Live attenuated versus inactivated influenza vaccine in infants and young children". The New England Journal of Medicine. 356 (7): 685–696. doi:10.1056/NEJMoa065368. PMID 17301299.
  9. ^ "FDA Information Regarding FluMist Quadrivalent Vaccine". U.S. Food and Drug Administration (FDA). 16 January 2018. Archived from the original on 28 November 2019. Retrieved 27 November 2019.
  10. ^ Midthun K, Masiello S (17 July 2003). "CBER Approval Letter, Influenza Virus Vaccine, Live, Intranasal (FluMist)". U.S. Food and Drug Administration (FDA). Archived from the original on 29 September 2007. Retrieved 6 July 2008.
  11. ^ "FluMist". U.S. Food and Drug Administration (FDA). Archived from the original on 22 July 2017. Retrieved 10 April 2020.
  12. ^ a b "FDA Approves Nasal Spray Influenza Vaccine for Self- or Caregiver-Administration". U.S. Food and Drug Administration. 20 September 2024. Retrieved 21 September 2024. Public Domain This article incorporates text from this source, which is in the public domain.
  13. ^ Jewett C (20 September 2024). "Nasal Flu Vaccine Is Approved for At-Home Use". The New York Times. Retrieved 24 September 2024.