Lord Charles Cavendish FRS (17 March 1704 – 28 April 1783) was a British nobleman and Whig politician.
Cavendish was the youngest son of William Cavendish, 2nd Duke of Devonshire, and Rachel Russell.
On 9 January 1727, Lord Charles Cavendish married Lady Anne de Grey (died 20 September 1733), daughter of Henry Grey, 1st Duke of Kent, and Jemima, his first wife. They had two children: Henry Cavendish (1731–1810), considered one of the most accomplished physicists and chemists of his era, and Frederick Cavendish (1733–1812).
Cavendish entered the House of Commons for Heytesbury in 1725 and would remain a member in various seats until 1741, when he turned the "family seat" of Derbyshire over to his nephew William Cavendish, Marquess of Hartington.