Lou Holtz may refer to:
- Lou Holtz (born 1937), American football coach
- His son, Lou Jr. (born 1964), also an American football coach, better known as Skip Holtz
- His grandson, Lou III (born 1994), an American football player and coach, better known as Trey Holtz
- Lou Holtz (actor) (1893–1980), an American vaudevillian, comic actor, and theatrical producer
- His son, Lou Jr., an American screenwriter of The Cable Guy (1996)
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