| Lucrezia Barberini | |
|---|---|
| Duchess of Modena | |
 | |
| Born | 24 October 1628 |
| Died | 24 August 1699 (aged 70) |
| Spouse | Francesco I d'Este, Duke of Modena |
| Issue | Rinaldo, Duke of Modena |
| Father | Taddeo Barberini, Prince of Palestrina |
| Mother | Anna Colonna |
Lucrezia Barberini (24 October 1628 – 24 August 1699) was an Italian noblewoman and, by marriage, Duchess of Modena. Born into the Barberini family, she was the last wife of Francesco I d'Este, Duke of Modena.