Luke Lea may refer to:
- Luke Lea (American politician, born 1783), U.S. Representative from Tennessee, 1833–1837
- Luke Lea (American politician, born 1879), U.S. Senator from Tennessee, 1911–1917; founder of The Tennessean newspaper
- Luke Lea, Commissioner of Indian Affairs 1850-1853
This disambiguation page lists articles about people with the same name.
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