Luzon earthquake may refer to:
- 1645 Luzon earthquake, the earthquake on Luzon Island in the Philippines that occurred on November 30, 1645
- 1880 Luzon earthquakes, the series of earthquakes that affected Manila and most of Luzon in July 1880
- 1990 Luzon earthquake, the earthquake on Luzon Island in the Philippines that occurred on July 16, 1990
- 1999 Luzon earthquake, the earthquake on Luzon Island in the Philippines that occurred on December 12, 1999
- 2019 Luzon earthquake, the earthquake on Luzon Island in the Philippines that occurred on April 22, 2019
- 2022 Luzon earthquake, the earthquake on Luzon Island in the Philippines that occurred on July 27, 2022