| LCP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | LCP2, SLP-76, SLP76, lymphocyte cytosolic protein 2, IMD81 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601603; MGI: 1321402; HomoloGene: 4065; GeneCards: LCP2; OMA:LCP2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa), also known as LCP2 or SLP-76, is a signal-transducing adaptor protein expressed in T cells and myeloid cells and is important in the signaling of T-cell receptors (TCRs).[5][6] As an adaptor protein, SLP-76 does not have catalytic functions, primarily binding other signaling proteins to form larger signaling complexes.[7] It is a key component of the signaling pathways of receptors with immunoreceptor tyrosine-based activation motifs (ITAMs) such as T-cell receptors, its precursors, and receptors for the Fc regions of certain antibodies.[7] SLP-76 is expressed in T-cells and related lymphocytes like natural killer cells.[8]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000043462 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002699 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)".
- ^ Pivniouk VI, Geha RS (April 2000). "The role of SLP-76 and LAT in lymphocyte development". Current Opinion in Immunology. 12 (2): 173–178. doi:10.1016/S0952-7915(99)00068-0. PMID 10712938.
- ^ a b Yablonski D, Weiss A (2001). Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and lat and their b cell counterpart, BLNK/SLP-65. Advances in Immunology. Vol. 79. pp. 93–128. doi:10.1016/S0065-2776(01)79003-7. ISBN 978-0-12-022479-1. PMID 11680012.
- ^ Kim HS, Long EO (July 2012). "Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells". Science Signaling. 5 (232): ra49. doi:10.1126/scisignal.2002754. PMC 3842037. PMID 22786724.