Lynestrenol

Lynestrenol
Clinical data
Trade namesExluton, Ministat, others
Other namesLinestrenol; Lynenol;[1] NSC-37725; 17α-Ethynylestr-4-en-17β-ol; 19-Nor-17α-pregn-4-en-20-yn-17-ol[1]
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth
Drug classProgestogen; Progestin
ATC code
Identifiers
  • (8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.000.139 Edit this at Wikidata
Chemical and physical data
FormulaC20H28O
Molar mass284.443 g·mol−1
3D model (JSmol)
  • C#C[C@]2(O)CC[C@H]1[C@H]4[C@H](CC[C@@]12C)[C@@H]3\C(=C/CCC3)CC4
  • InChI=1S/C20H28O/c1-3-20(21)13-11-18-17-9-8-14-6-4-5-7-15(14)16(17)10-12-19(18,20)2/h1,6,15-18,21H,4-5,7-13H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1 checkY
  • Key:YNVGQYHLRCDXFQ-XGXHKTLJSA-N checkY
  (verify)

Lynestrenol, sold under the brand names Exluton and Ministat among others, is a progestin medication which is used in birth control pills and in the treatment of gynecological disorders.[2][3][4] The medication is available both alone and in combination with an estrogen.[3][5][6] It is taken by mouth.[7][8]

Lynestrenol is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.[9] It has weak androgenic and estrogenic activity and no other important hormonal activity.[9][10] The medication is a prodrug of norethisterone in the body, with etynodiol occurring as an intermediate.[10][11][12]

Lynestrenol was discovered in the late 1950s and was introduced for medical use in 1961.[13][14] It has mostly been used in Europe and elsewhere in the world and was never marketed in the United States.[6][15][16][17]

  1. ^ a b Cite error: The named reference UnitedNations was invoked but never defined (see the help page).
  2. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 747–. ISBN 978-1-4757-2085-3.
  3. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 624–. ISBN 978-3-88763-075-1.
  4. ^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 170–. ISBN 978-94-011-4439-1.
  5. ^ Cite error: The named reference Muller1998 was invoked but never defined (see the help page).
  6. ^ a b "Lynestreno". Drugs.com l.
  7. ^ Cite error: The named reference pmid436304 was invoked but never defined (see the help page).
  8. ^ Cite error: The named reference pmid18356043 was invoked but never defined (see the help page).
  9. ^ a b Cite error: The named reference pmid19434889 was invoked but never defined (see the help page).
  10. ^ a b Kuhl H (August 2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 (Suppl 1): 3–63. doi:10.1080/13697130500148875. PMID 16112947. S2CID 24616324.
  11. ^ Cite error: The named reference pmid12215716 was invoked but never defined (see the help page).
  12. ^ Cite error: The named reference pmid2256526 was invoked but never defined (see the help page).
  13. ^ Cite error: The named reference Gijswijt-HofstraHeteren2002 was invoked but never defined (see the help page).
  14. ^ Cite error: The named reference GaleResearch1991 was invoked but never defined (see the help page).
  15. ^ Cite error: The named reference LoboKelsey2000 was invoked but never defined (see the help page).
  16. ^ Cite error: The named reference Gelijns1991 was invoked but never defined (see the help page).
  17. ^ Cite error: The named reference FDA was invoked but never defined (see the help page).