Lyon-Perrache or simply Perrache (French: Gare de Lyon-Perrache, [ɡaʁ də ljɔ̃ pɛʁaʃ]) is a large railway station located in the Perrache quarter, in the 2nd arrondissement of Lyon, France. Historically the primary railway station in Lyon, today it is the city's second-busiest station, after the newer Lyon-Part-Dieu station.
Opened in 1857 on Lyon's Presqu'île, the station is located on the Paris–Marseille railway, Lyon–Geneva railway and Moret–Lyon railway. The train services are operated by the SNCF and include TGV, Intercités, TER and international services.