Lysyl oxidase

LOX
Identifiers
AliasesLOX, entrez:4015, lysyl oxidase, AAT10, Lysyl oxidase
External IDsOMIM: 153455; MGI: 96817; HomoloGene: 1741; GeneCards: LOX; OMA:LOX - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002317
NM_001178102
NM_001317073

NM_010728
NM_001286181
NM_001286182

RefSeq (protein)

NP_001171573
NP_001304002
NP_002308

NP_001273110
NP_001273111
NP_034858

Location (UCSC)Chr 5: 122.06 – 122.08 MbChr 18: 52.65 – 52.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysyl oxidase (LOX), also known as protein-lysine 6-oxidase, is an enzyme that, in humans, is encoded by the LOX gene.[5][6] It catalyzes the conversion of lysine residues into its aldehyde derivative allysine.[7] Allysine form cross-links in extracellular matrix proteins. Inhibition of lysyl oxidase can cause osteolathyrism, but, at the same time, its upregulation by tumor cells may promote metastasis of the existing tumor, causing it to become malignant and cancerous.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113083Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024529Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: LOX lysyl oxidase".
  6. ^ Hämäläinen ER, Jones TA, Sheer D, Taskinen K, Pihlajaniemi T, Kivirikko KI (Nov 1991). "Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2". Genomics. 11 (3): 508–16. doi:10.1016/0888-7543(91)90057-L. PMID 1685472.
  7. ^ Requena JR, Levine RL, Stadtman ER (2003). "Recent Advances in the Analysis of Oxidized Proteins". Amino Acids. 25 (3–4): 221–226. doi:10.1007/s00726-003-0012-1. PMID 14661085. S2CID 28837698.