MAP1LC3B

MAP1LC3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V49, 2LUE, 2ZJD, 3VTU, 3VTV, 3VTW, 3WAO, 3X0W, 4WAA, 5D94, 5DCN
Identifiers
Aliases	MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a, microtubule associated protein 1 light chain 3 beta
External IDs	OMIM: 609604; MGI: 1914693; HomoloGene: 69359; GeneCards: MAP1LC3B; OMA:MAP1LC3B - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.2 Start 87,383,953 bp[1] End 87,404,779 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 122,317,100 bp[2] End 122,325,499 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in paraflocculus of cerebellum pars compacta Brodmann area 10 pars reticulata lateral nuclear group of thalamus frontal pole C1 segment postcentral gyrus external globus pallidus pons Top expressed in external carotid artery morula deep cerebellar nuclei internal carotid artery medial vestibular nucleus blastocyst pontine nuclei iris ciliary body dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding microtubule binding Cellular component cytoplasm organelle membrane membrane intracellular anatomical structure mitochondrion axoneme microtubule cytoskeleton cytoplasmic vesicle endomembrane system autophagosome membrane cytosol autophagosome autolysosome Biological process autophagy of mitochondrion autophagosome assembly autophagy cellular response to nitrogen starvation cellular response to starvation macroautophagy autophagosome maturation positive regulation of mucus secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81631 67443 Ensembl ENSG00000140941 ENSMUSG00000031812 UniProt Q9GZQ8 Q9CQV6 RefSeq (mRNA) NM_022818 NM_026160 NM_001364358 RefSeq (protein) NP_073729 NP_080436 NP_001351287 Location (UCSC) Chr 16: 87.38 – 87.4 Mb Chr 8: 122.32 – 122.33 Mb PubMed search [3] [4]
Wikidata
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Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene.^[5] LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes.^[6]