MAP2K1

MAP2K1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S9J, 2P55, 3DV3, 3DY7, 3E8N, 3EQB, 3EQC, 3EQD, 3EQF, 3EQG, 3EQH, 3EQI, 3MBL, 3ORN, 3OS3, 3PP1, 3SLS, 3V01, 3V04, 3VVH, 3W8Q, 3WIG, 3ZLS, 3ZLW, 3ZLX, 3ZLY, 3ZM4, 4AN2, 4AN3, 4AN9, 4ANB, 4ARK, 4LMN, 4MNE, 4U7Z, 4U80, 4U81, 5BX0
Identifiers
Aliases	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1, mitogen-activated protein kinase kinase 1, MEL
External IDs	OMIM: 176872; MGI: 1346866; HomoloGene: 2063; GeneCards: MAP2K1; OMA:MAP2K1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	66,491,656 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	64,160,913 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; orbitofrontal cortex; ; prefrontal cortex; ; postcentral gyrus; ; Brodmann area 46; ; Brodmann area 9; ; superior frontal gyrus; ; nucleus accumbens; ; Skeletal muscle tissue of rectus abdominis; ; cingulate gyrus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; olfactory tubercle; ; nucleus accumbens; ; superior frontal gyrus; ; zygote; ; hippocampus proper; ; secondary oocyte; ; temporal lobe; ; amygdala; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; kinase activity; protein C-terminus binding; ATP binding; transferase activity; protein serine/threonine kinase activator activity; protein binding; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; nucleotide binding; MAP kinase kinase activity; protein kinase activity; protein serine/threonine kinase activity; scaffold protein binding;
Cellular component	membrane; focal adhesion; microtubule organizing center; mitochondrion; cytoskeleton; nucleus; endoplasmic reticulum; late endosome; Golgi apparatus; early endosome; cytoplasm; cytosol; plasma membrane;
Biological process	regulation of protein phosphorylation; positive regulation of axonogenesis; positive regulation of protein serine/threonine kinase activity; cellular senescence; face development; cerebellar cortex formation; negative regulation of cell population proliferation; thymus development; cell motility; negative regulation of gene expression; heart development; positive regulation of cell differentiation; regulation of stress-activated MAPK cascade; phosphorylation; epithelial cell proliferation involved in lung morphogenesis; chemotaxis; thyroid gland development; neuron differentiation; trachea formation; regulation of axon regeneration; lung morphogenesis; regulation of early endosome to late endosome transport; labyrinthine layer development; placenta blood vessel development; keratinocyte differentiation; MAPK cascade; positive regulation of gene expression; Bergmann glial cell differentiation; peptidyl-tyrosine phosphorylation; regulation of Golgi inheritance; signal transduction; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of ERK1 and ERK2 cascade; positive regulation of transcription, DNA-templated; regulation of mitotic cell cycle; regulation of apoptotic process; protein phosphorylation; peptidyl-threonine phosphorylation; ERK1 and ERK2 cascade; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	5604
	26395
	ENSG00000169032
	ENSMUSG00000004936
	Q02750
	P31938
	NM_002755
	NM_008927
	NP_002746
	NP_032953
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169032 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004936 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5". Cytogenet Cell Genet. 78 (3–4): 301–3. doi:10.1159/000134677. hdl:11577/2469645. PMID 9465908.
^ Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem. 268 (15): 11435–9. doi:10.1016/S0021-9258(18)82142-1. PMID 8388392.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169032 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004936 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9465908-5] Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5". Cytogenet Cell Genet. 78 (3–4): 301–3. doi:10.1159/000134677. hdl:11577/2469645. PMID 9465908.

[pmid8388392-6] Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem. 268 (15): 11435–9. doi:10.1016/S0021-9258(18)82142-1. PMID 8388392.

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