MAP2K5

MAP2K5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NPT, 2O2V, 4IC7
Identifiers
Aliases	MAP2K5, HsT17454, MAPKK5, MEK5, PRKMK5, mitogen-activated protein kinase kinase 5
External IDs	OMIM: 602520; MGI: 1346345; HomoloGene: 115933; GeneCards: MAP2K5; OMA:MAP2K5 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	67,807,117 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	63,285,184 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; parotid gland; ; gonad; ; right frontal lobe; ; Achilles tendon; ; gastrocnemius muscle; ; ventricular zone; ; Brodmann area 9; ; prefrontal cortex;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; motor neuron; ; Rostral migratory stream; ; spermatocyte; ; CA3 field; ; right kidney; ; seminiferous tubule; ; primitive streak; ; left lobe of liver;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein binding; protein tyrosine kinase activity; ATP binding; protein serine/threonine kinase activity; MAP kinase kinase activity;
Cellular component	cytoplasm; cytosol; spindle; nucleus; intracellular anatomical structure;
Biological process	negative regulation of chemokine (C-X-C motif) ligand 2 production; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; phosphorylation; positive regulation of epithelial cell proliferation; cellular response to laminar fluid shear stress; cellular response to growth factor stimulus; negative regulation of transcription by RNA polymerase II; negative regulation of response to cytokine stimulus; MAPK cascade; ERK5 cascade; negative regulation of cell migration involved in sprouting angiogenesis; protein phosphorylation; heart development; positive regulation of cell growth; peptidyl-tyrosine phosphorylation; negative regulation of heterotypic cell-cell adhesion; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of NF-kappaB transcription factor activity; signal transduction; positive regulation of transcription by RNA polymerase II; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	5607
	23938
	ENSG00000137764
	ENSMUSG00000058444
	Q13163
	Q9WVS7
	NM_001206804; NM_002757; NM_145160; NM_145161; NM_145162
	NM_011840; NM_001364492; NM_001364493; NM_001364494
	NP_001193733; NP_002748; NP_660143
	NP_035970; NP_001351421; NP_001351422; NP_001351423
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137764 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058444 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhou G, Bao ZQ, Dixon JE (May 1995). "Components of a new human protein kinase signal transduction pathway". The Journal of Biological Chemistry. 270 (21): 12665–9. doi:10.1074/jbc.270.21.12665. PMID 7759517.
^ "Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137764 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058444 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7759517-5] Zhou G, Bao ZQ, Dixon JE (May 1995). "Components of a new human protein kinase signal transduction pathway". The Journal of Biological Chemistry. 270 (21): 12665–9. doi:10.1074/jbc.270.21.12665. PMID 7759517.

[entrez-6] "Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5".

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