MAP3K1

MAP3K1
Identifiers
Aliases	MAP3K1, MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6, mitogen-activated protein kinase kinase kinase 1
External IDs	OMIM: 600982; MGI: 1346872; HomoloGene: 8056; GeneCards: MAP3K1; OMA:MAP3K1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	56,896,152 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	111,945,527 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; skin of thigh; ; skin of hip; ; parotid gland; ; corpus epididymis; ; monocyte; ; vulva; ; oral cavity; ; lactiferous duct; ; gums;
	Top expressed in
	corneal stroma; ; submandibular gland; ; lactiferous gland; ; parotid gland; ; cumulus cell; ; blood; ; epithelium of stomach; ; neural layer of retina; ; Ileal epithelium; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; zinc ion binding; metal ion binding; kinase activity; protein binding; MAP kinase kinase kinase activity; ATP binding; protein kinase binding; protein kinase activity; protein serine/threonine kinase activity;
Cellular component	cytoplasm; cytosol;
Biological process	phosphorylation; MyD88-dependent toll-like receptor signaling pathway; Fc-epsilon receptor signaling pathway; protein phosphorylation; cellular response to mechanical stimulus; MAPK cascade; regulation of mitotic cell cycle; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	4214
	26401
	ENSG00000095015
	ENSMUSG00000021754
	Q13233
	P53349
	NM_005921
	NM_011945
	NP_005912
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is a signal transduction enzyme that in humans is encoded by the autosomal MAP3K1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095015 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021754 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vinik BS, Kay ES, Fiedorek FT (November 1995). "Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5". Mammalian Genome. 6 (11): 782–783. doi:10.1007/BF00539003. PMID 8597633. S2CID 37828255.
^ "Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095015 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021754 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8597633-5] Vinik BS, Kay ES, Fiedorek FT (November 1995). "Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5". Mammalian Genome. 6 (11): 782–783. doi:10.1007/BF00539003. PMID 8597633. S2CID 37828255.

[entrez-6] "Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1".

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