MAP4K1

MAP4K1
Identifiers
Aliases	MAP4K1, HPK1, mitogen-activated protein kinase kinase kinase kinase 1
External IDs	OMIM: 601983; MGI: 1346882; HomoloGene: 5199; GeneCards: MAP4K1; OMA:MAP4K1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,618,882 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,702,704 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; spleen; ; appendix; ; bone marrow cells; ; blood; ; monocyte; ; tonsil; ; testicle; ; sural nerve;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; thymus; ; spermatid; ; blood; ; ankle joint; ; morula; ; granulocyte; ; embryo; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; MAP kinase kinase kinase kinase activity; protein serine/threonine kinase activity; nucleotide binding; protein binding; ATP binding; kinase activity;
Cellular component	cytoplasm; membrane; intracellular anatomical structure;
Biological process	protein autophosphorylation; protein phosphorylation; response to stress; cell population proliferation; intracellular signal transduction; peptidyl-serine phosphorylation; phosphorylation; regulation of mitotic cell cycle; regulation of apoptotic process; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity; cellular response to phorbol 13-acetate 12-myristate;
	Sources:Amigo / QuickGO
Orthologs
	11184
	26411
	ENSG00000282928; ENSG00000104814
	ENSMUSG00000037337
	Q92918
	P70218
	NM_001042600; NM_007181
	NM_008279; NM_001355054
	NP_001036065; NP_009112
	NP_032305; NP_001341983
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.^[5] It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation.^[6]

^ ^a ^b ^c ENSG00000104814 GRCh38: Ensembl release 89: ENSG00000282928, ENSG00000104814 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037337 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev. 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585.
^ Chuang HC, Wang X, Tan TH (2016). MAP4K Family Kinases in Immunity and Inflammation. Advances in Immunology. Vol. 129. pp. 277–314. doi:10.1016/bs.ai.2015.09.006. ISBN 9780128047996. PMID 26791862. {{cite book}}: |journal= ignored (help)

[refGRCh38Ensembl-1] ENSG00000104814 GRCh38: Ensembl release 89: ENSG00000282928, ENSG00000104814 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037337 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8824585-5] Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev. 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585.

[6] Chuang HC, Wang X, Tan TH (2016). MAP4K Family Kinases in Immunity and Inflammation. Advances in Immunology. Vol. 129. pp. 277–314. doi:10.1016/bs.ai.2015.09.006. ISBN 9780128047996. PMID 26791862. {{cite book}}: |journal= ignored (help)

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