MAP4K5

MAP4K5
Identifiers
Aliases	MAP4K5, GCKR, KHS, KHS1, MAPKKKK5, mitogen-activated protein kinase kinase kinase kinase 5
External IDs	OMIM: 604923; MGI: 1925503; HomoloGene: 38199; GeneCards: MAP4K5; OMA:MAP4K5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	50,561,126 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	69,939,974 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; sural nerve; ; Achilles tendon; ; tibia; ; canal of the cervix; ; ectocervix; ; body of uterus; ; C1 segment; ; germinal epithelium; ; left ovary;
	Top expressed in
	secondary oocyte; ; zygote; ; interventricular septum; ; primary oocyte; ; genital tubercle; ; atrium; ; dermis; ; mandibular prominence; ; maxillary prominence; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; protein serine/threonine kinase activity; nucleotide binding; protein binding; ATP binding; kinase activity; MAP kinase kinase kinase kinase activity;
Cellular component	cytoplasm;
Biological process	protein phosphorylation; intracellular signal transduction; phosphorylation; regulation of mitotic cell cycle; regulation of apoptotic process; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	11183
	399510
	ENSG00000012983
	ENSMUSG00000034761
	Q9Y4K4
	Q8BPM2
	NM_006575; NM_198794
	NM_201519
	NP_006566; NP_942089
	NP_958927
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene.^[5]^[6]^[7]

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000012983 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034761 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tung RM, Blenis J (March 1997). "A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase". Oncogene. 14 (6): 653–9. doi:10.1038/sj.onc.1200877. PMID 9038372.
^ Schultz SJ, Nigg EA (February 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
^ ^a ^b "Entrez Gene: MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000012983 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034761 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9038372-5] Tung RM, Blenis J (March 1997). "A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase". Oncogene. 14 (6): 653–9. doi:10.1038/sj.onc.1200877. PMID 9038372.

[pmid8274451-6] Schultz SJ, Nigg EA (February 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.

[entrez-7] "Entrez Gene: MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5".

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